Serum paraoxonase activity in secondary dyslipidemias

1.1. Lipoprotein abnormalities in atherosclerosis, the role of high-density lipoprotein (HDL) The inverse relationship between plasma levels of HDL and coronary heart disease (CHD) has been demonstrated in a number of observational epidemiological studies, such as Framingham Heart Study, and Prospective Cardiovascular Münster Study (PROCAM), as well as in several intervention studies, for example Familial Atherosclerosis Treatment Study (FATS), which showed that increased HDL concentrations independently predicted lowered risk of CHD. Results of the High-Density Lipoprotein Intervention Trial (VA-HIT study) also suggest that the rate of coronary events may be reduced by raising HDL cholesterol and lowering triglyceride concentration independent of LDL cholesterol levels in subjects with CHD whose primary lipid phenotype was low HDL-high triglyceride levels.